Treatment for improving gut microbiome found safe in ALS
Dec 6, 2024 · Research has shown that people with ALS have abnormal gut microbiota, and mouse models of the disease have suggested that microbiome dysregulation can exacerbate neurodegeneration and reduce survival.. Maat Pharma’s MaaT033 is designed to restore the microbiome balance in ALS patients to potentially help slow disease progression when given along standard ALS treatments.
Phase 3 trial of oral pridopidine in treating ALS likely this year
Jan 29, 2024 · The HEALEY ALS (NCT04297683) platform trial is designed to simultaneously evaluate multiple experimental ALS treatments against a shared placebo group. It is being led by researchers at the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital in Boston. The Phase 2/3 pridopidine arm (NCT04615923) enrolled 163 adults with clinically possible, probable, or definite ALS, whose ...
Clene granted in-person FDA meeting on CNM-Au8 for ALS
Sep 24, 2024 · Clene has been granted an in-person meeting with the U.S. Food and Drug Administration (FDA) — to be held before the end of November, according to the company — to discuss a potential accelerated approval of CNM-Au8 …
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Dec 13, 2024 · Muscle mass biomarker is associated with risk of developing ALS: Study. A muscle mass biomarker called the creatinine-to-cystatin C ratio (CCR) may indicate the risk of developing amyotrophic lateral sclerosis (ALS), a study that relied on a …
Neuvivo requests FDA approval of ALS treatment NP001
Oct 9, 2024 · The new drug application comes on the heels of combined data from Phase 2a (NCT01281631) and Phase 2b (NCT02794857) clinical trials, in which NP001 slowed disease progression and preserved lung function in a subset of ALS patients with high levels of inflammation.. If approved, NP001 could be the first disease-modifying therapy for ALS designed to restore the balance of the innate immune ...
A new experience at home is especially meaningful with ALS
Dec 5, 2024 · Being homebound is hard on the psyche in later stages of ALS.We don’t go out now that my husband, Todd, needs noninvasive ventilation to breathe and his neck is so weak that it’s uncomfortable to ride in his accessible van. We miss life before ALS, when we had new experiences like vacations to faraway places and interesting food at new restaurants.
6 simple habits that help me with living with ALS
Oct 8, 2024 · These are habits that I believe you’ll find helpful as well, and I’m excited to share them with you here. A morning stretch. Although I sleep well at night, my ALS symptoms cause me to wake up in the morning with tight muscles, feeling stiff and wobbly on my feet. Now, I linger in bed and take the time to perform gentle stretches, a few twists, and even rolling side to side.
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Tiziana wins funding for small clinical trial in ALS of intranasal ...
Nov 22, 2024 · The upcoming trial intends to investigate the safety and effectiveness of two foralumab doses in 20 ALS patients. It builds on positive findings from multiple sclerosis (MS) patients, in whom the intranasal antibody therapy significantly decreased neuroinflammation and stabilized or reduced disability levels. Tiziana now wants to …