The genetic disease harlequin ichthyosis affects the transport of fats within the skin, resulting in hard, scalelike plaques ...

Kate Middleton canceled her appearance at the 2025 Royal Ascot at the last minute on June 18, though the palace expressed the ...

Even without bacteria present, the PolG cells kept producing high levels of an inflammatory molecule called type I interferon. This, in turn, activated a bacterial sensor called caspase-11 ...

Researchers from Pretzel Therapeutics Inc. and the University of Gothenburg have published new insights on how mutations in the POLG gene affect its functionality and are tied to PolG diseases. They ...

For POLG-related disorders, heterogeneity means that patients may have different mutations in the POLG gene, leading to varied symptoms and severities. Deoxynucleotide triphosphates (dNTPs) The ...

PZL-A works by binding to POLG and stabilizing it, helping the mutant POLG stay on the circular mtDNA longer, which in turn helps it copy and repair more of it (Nature 2025, DOI: 10.1038/s41586 ...

WALTHAM, Mass., April 09, 2025--Pretzel Therapeutics, a leader in harnessing cellular energetics to develop novel treatments for a range of conditions spanning neurological, muscular atrophies ...

- First-in human clinical study recently initiated with PX578, lead POLG activator therapeutic in Pretzel’s bioenergetics restoration franchise The study, conducted in collaboration with Pretzel ...

POLG mutations are the most common cause of inherited mitochondrial disorders, with around 300 mutations in POLG known to cause disease. Examples of POLG-related diseases include Alpers ...