Familial hypercholesterolemia results from gene mutations approximately halving the number of functional LDL receptors in heterozygotes and a greater lack in homozygotes. Reduced receptor-mediated ...

Coronary heart disease (CHD) is a leading cause of morbidity and mortality globally. Hypercholesterolemia is one of the major risk factors for CHD. With the increase in aging populations and ...

2016). Recently, a study in a FH mouse model with a non-viral vector expressing LDLR cDNA combined with a microRNA which suppresses the 3-hydroxy-3-methylglutaryl-coenzyme A reductase (Hmgcr) has also ...