From Brownlee M: Biochemistry and molecular cell biology of diabetic complications. Nature 414:813-820, 2001. The third mechanism on my "pieces of the puzzle" list was the PKC pathway.

The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway.

This may be due to involvement of PKC in cellular proliferation, 44 45 the decline of which has been shown to be necessary for the onset of osteoblastic differentiation. 36 The results also showed ...

With a strong foundation laid over the past four years, the S&T Clusters model is emerging as an effective bridge between lab-scale innovation and field-scale implementation.