Much less commonly, p53 mutations can be inherited, and give rise to a syndrome known as Li-Fraumeni syndrome. EGFR mutations with lung cancer are usually somatic mutations acquired in the process ...

All the various tp53 and Trp53 clones used in cancer studies came from transformed cell lines; they all contained mutations. Once researchers redefined p53 as a tumor suppressor gene and generated ...

In about every second case of tumor such a mutation of the p53 protein can be detected. Cancer researchers are therefore striving to better understand and counteract the mutations. Read the full ...

Other cancer-related mutations inactivate the genes that suppress ... many cancer cells carry two mutant copies of the gene that codes for p53, a multifunctional protein that normally senses ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

Sponsored by the biology department and the Michael J. Wolk Foundation, Alea Mills, a professor at Cold Spring Harbor ...

PMV Pharmaceuticals, Inc.’s PMVP share price has surged by 7.83%, which has investors questioning if this is right time to ...

Cancer arises through an evolutionary process whereby normal cells acquire mutations that erode growth controls ... Modeling the therapeutic efficacy of p53 restoration in tumors. Cell.