The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.

Disruption of core clock genes promotes tumor initiation and progression by regulating mechanisms such as the cell cycle, DNA repair, apoptosis ... of the p53-MDM2 pathway and DNA repair factors ...

RPL9 knockdown promote the apoptosis of B-ALL cells ... The findings indicate that RPL9 KD trigger nucleolar stress and activates the p53 signaling pathway in B-ALL cells. 3.6 Knocking down RPL9 ...

Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch (UTMB), Galveston, Texas 77555, United States ...

Myocardial infarction (MI) elicits mitochondria reactive oxygen species (ROS) production and cardiomyocyte (CM) apoptosis. Nrf3 (nuclear factor ... the in vivo relevance of the identified signal ...

Recent studies have shown that miRNAs regulating cell proliferation, differentiation and apoptosis could act through overlapping pathways linking cancer and dementia. Member miRNAs of the miR-29 ...

This, in turn, induces CD8 + T cell exhaustion and apoptosis while suppressing their ... upregulated by the TGF-β signaling pathway, targets CDK9 in CD8 + T cells via EVs, inhibiting CD8 ...

Best practice timed pathways support the ongoing improvement effort to shorten diagnosis pathways, reduce variation, improve experience of care, and meet the Faster Diagnosis Standard (FDS). The ...

When these genetically damaged cells are not fixed or eliminated, they can go on to multiply uncontrollability. A protein known as p53 can help to repress emerging tumors by stopping mutated cells in ...

During your time with Pathways to Medicine, you will participate in events and activities throughout Year 12 and 13. Every aspect of the programme is designed to help you make a strong and informed ...