To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

Trump misstated $8 million spent on transgender mice, sparking debate on transgenic research and its importance in science.

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

Colossal Biosciences leaders say the fluffy, golden-haired mice help validate their technique to “de-extinct” species, but ...

However, the role of the Nwd1 gene in SERCA2 activity and the ... The team created an Nwd1 knockout (Nwd1 −/−) mice model ...

A research team led by Prof. Zhang Xin from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences has revealed how magnetic properties in mice vary under different physiological ...

To generate a tissue specific knockout mouse, researchers breed a mouse bearing a Cre transgene under a tissue- or cell-type specific or inducible promoter (A) with a homozygous floxed mouse (B). The ...

The team then edited the mouse genome using a streamlined strategy that combined three editing technologies: RNP-mediated knockout ... to modify seven genes. The gene editing resulted in mice ...

By replacing the defective gene associated with Dravet syndrome in mice, scientists successfully alleviated symptoms without ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a polygenic disorder influenced by multiple genes, but their specific roles in the progression of disease remain unknown. To address this gap ...

To address this gap, researchers conducted a series of experiments that identified the NACHT and WD repeat domain-containing protein 1 (Nwd1) gene and its role in liver pathogenesis. This ...