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Evolutionary analysis uncovers protein changes that protect mammals from aging and disease
Over recent decades, humanity has witnessed a remarkable and continuous increase in lifespan. However, this advancement has ...
C&EN27d
Dimethyl Sulfate as Methylation Agent and Solvent in Highly Regioselective Synthesis of Methyl Salicylate Using Sodium Bicarbonate as a Base
Department of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil ...
C&EN1mon
Continuous Sustainable Production of Biobased Multicomponent Enhanced Resin for SLA 3D Printing
This work focuses on biobased reactive diluents’ synthesis, continuing with optimized oil-based resin precursor production. Our approach introduces vanillin methacrylate (VanMMA), cinnamyl ...
Frontiers2y
The role of polyamine metabolism in remodeling immune responses and blocking therapy within the tumor immune microenvironment
The polyamine catabolism process occurs through the action of amine oxidase, mainly polyamine oxidase (PAOX) and spermine oxidase (SMOX). PAOX and SMOX can generate a large amount of reactive oxygen ...
Frontiers3y
Lymph Node-Targeted Synthetically Glycosylated Antigen Leads to Antigen-Specific Immunological Tolerance
The objective of this study was to target synthetically glycosylated antigen to LN APCs to induce antigen-specific immunological tolerance, and investigate the molecular mechanisms of tolerance ...
eLife8y
SIRT6 regulates Ras-related protein R-Ras2 by lysine defatty-acylation
Understanding their regulation is thus important for studying biology and human diseases. Here, we report that a novel posttranslational mechanism, reversible lysine fatty acylation, regulates R-Ras2, ...