The 49ers were already out of playoff contention, and the Lions had little to play for, but that didn’t stop fans from tuning in on Monday night. Lions-49ers was the most-watched Monday Night Football ...

Tensions were high in the first quarter of a Monday night game between the Detroit Lions and the San Francisco 49ers. The Lions were looking for one more win to build momentum ahead of an NFC ...

With last place in the NFC West clinched, the 49ers know exactly which teams they will face during the 2025 NFL season. The order in which they face them, however, remains to be seen. San ...

Brock Purdy threw for a career-high 377 yards and three touchdowns as the San Francisco 49ers fell to the Detroit Lions 40-34 at Levi's Stadium on Monday Night Football. Purdy also threw two ...

The Detroit Lions technically didn’t need to win Monday night’s matchup with the San Francisco 49ers, begging the question of whether head coach Dan Campbell would pull his starters at some ...

The last time the 49ers hosted the Detroit Lions, the stakes could hardly be higher. It was the NFC title game, and the 49ers came back from a 17-point halftime deficit to win, 34-31, and advance ...

The Detroit Lions scored on five consecutive drives in the second half to pull away for a 40-34 win over the host San Francisco 49ers on the final "Monday Night Football" matchup of the season.

The Lions (14-2) took down the San Francisco 49ers (6-10) 40-34 at Levi's Stadium in a high-scoring win. Detroit got a win on the same field where their 2023 season came to an abrupt end one game ...

The 49ers were officially eliminated from the playoff picture ahead of their Week 16 game against the Dolphins. They failed to qualify for the postseason for the first time since 2020. San ...

So, it’s come to this: no matter what the Detroit Lions do on Monday night in Week 17 against the San Francisco 49ers, they’ll be playing for the NFC North title against the Minnesota Vikings ...

Yes, some of the luster has rubbed off the Detroit Lions’ matchup tonight with the San Francisco 49ers. The rematch of January’s NFC championship game — have you heard? — is more for ...

The 49ers are riding a tow game losing streak into Week 17. They are poised to increase it to three in their matchup with the Lions. Here are three reasons why the 49ers will lose to the Lions.