Gene expression is linked to RNA transcription, which cannot happen without RNA polymerase. However, this is where the similarities between prokaryote and eukaryote expression end. Central to the ...

Once transcription is initiated, the DNA double helix unwinds and RNA polymerase reads the template strand, adding nucleotides to the 3′ end of the growing chain (Figure 2b). At a temperature of ...

Shawna was an editor at The Scientist from 2017 through 2022. She holds a bachelor's degree in biochemistry from Colorado College and a graduate certificate and science communication from the ...

An enzyme called RNA polymerase deciphers this code and converts it into RNA, a molecule that closely resembles DNA. This transfer of life's code from DNA to RNA is called transcription.

Mediator is a common target of DNA-binding transcription factors (TFs) and also interacts with various Pre-Initiation Complex (PIC) factors. The PIC consists of TFIIA, TFIIB, TFIID, TFIIE, TFIIF, ...

In prokaryotes, which lack a distinct nucleus and internal membrane boundaries, transcription and translation occur ...

These insights from researchers could have major implications for diseases like cancer, where gene expression goes awry.

RNA synthesis, or transcription, is the process by which RNA is produced using DNA as a template. This process is carried out by the enzyme RNA polymerase, which binds to specific promoter regions on ...

Northwestern Medicine scientists have uncovered how a testis-specific protein contributes to tumor growth and progression in ...

Ibrahim Cissé spent hours as a child taking apart and trying to rebuild electronics. Other times, he would reenact NASA space shuttle liftoffs, tipping a chair backward onto the floor and then ...

The RNA cloud formed around genes regulates their readout into RNA. Triplexes help define where in the genome a cloud forms. Proteins and other fl ...

Lung cancer (LC) is a major global health issue, with high mortality rates and limited therapeutic options. It is primarily categorized into non-small cell lung cancer (NSCLC) and small cell lung ...