X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Paget disease of bone is a chronic skeletal disorder, common in European populations, that is characterized by abnormal bone remodeling. This disorder can involve one or several bones and is ...

One individual probably suffered from Pagets disease while another appeared to have been severely disabled from bones recovered at the site. Significantly, the human bones were intermingled with ...

Supplements may be needed to correct vitamin A levels. Paget’s Disease Paget’s disease is a condition that makes the bones in the body grow too much. Paget’s can affect bones throughout the body, ...

If the disease progresses, it causes new bone development. As a result, vertebrae can fuse together. 6. Paget's Disease of Bone Paget’s is a chronic bone disorder that causes rapid and excessive ...

In an exclusive interview with PEOPLE, Jay and Pamela — both born with osteogenesis imperfecta, or brittle bone disease — open up about keeping a positive mindset despite challenges. They are starring ...

Historical trends and future projections of the number of people with overweight and obesity suggest alarming parallel ...

It's no coincidence that our bodies feel a little creakier as we age. The trillions of cells that make up our skeleton age ...