Bladder instillation of Escherichia coli lipopolysaccharide alters the muscle contractions in rat urinary bladder via a protein kinase C-related pathway. Toxicol Appl Pharmacol 2005;208:163–169.

Most proteome changes, in particular upon 40 Gy IR, affected mitogenic signaling events controlling cell survival (MKK3/6-p38-MK2 pathway, MEK-ERK pathway, LKB-AMPK pathway, PKC-Bad pathway).

It also activates the classic PKC pathway, since the activator of PKC, diacylglycerol, is also formed from glyceraldehyde-3 phosphate. (Enlarge Image) ...

Other molecules targeting the PKC pathway have been tried, but failed. For example, sotrastaurin, a pan-inhibitor of PKC isoforms showed drug activity but did not result in high response rates.

PKC, PKA, and PKG pathways control posttranslational regulation of receptor and channel proteins, and also have influences on gene expression.

That’s because they’re likely acting far upstream of where a key problem is, namely in the PKC pathway. Since PKC inhibitors could act more directly, they might quench symptoms more quickly.

Signaling Pathway through Which Nicotine Promotes Breast Cancer Migration Discovered October 15, 2008 Nicotine interacts with its receptor to trigger a signaling cascade involving PKC and cdc42 ...

Working with mouse models, he genetically blocked the pathway glutamine uses to fuel cells in hair follicle stem cells—a known cell type of origin for squamous cell skin cancer—and observed ...

One of the key proteins is protein kinase C [PKC]. We found a tremendous amount of biological validation for the existence and use of this pathway in both parasitic organisms." ...

TTP LabTech has highlighted the use of the Acumen® eX3 laser scanning imaging cytometer to elucidate novel cellular pathways involved in the shedding of the epidermal growth factor receptor (EGFR).

Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...