The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway.

Background: Protein kinase C-β2 (PKCβ2) is a splice-variant of the PRKCB1 gene and belongs to a family of serine/threonine-specific kinases that are predominantly activated by diacylglycerol ...

Prostate-associated gene 4 (PAGE4) is a cancer/testis antigen that is typically restricted to the testicular germ cells but is aberrantly expressed in cancer. Furthermore, PAGE4 is developmentally ...

Although the function of the p42/p44 mitogen-activated protein (MAP) kinase pathway in long-term potentiation at hippocampal CA3–CA1 synapses has been well described, relatively little is known ...

Bachelor's degree at SRU to help address state's shortage of registered nurses SLIPPERY ROCK, Pa., June 17, 2025 /PRNewswire/ -- Pennsylvania is facing a critical shortage of nurses, with recent ...

Electroencephalogram (EEG)-based Brain-Computer Interfaces (BCIs) have gained substantial attention, particularly for motor imagery (MI) that facilitates direct brain-to-device communication without ...

Don’t use too much credit The second-largest factor in a credit report, accounting for 30%, is “ amounts owed.” That metric refers to credit utilization: how much of your available credit ...

The stress-inducible protein heme oxygenase-1 provides protection against oxidative stress. The anti-inflammatory properties of heme oxygenase-1 may serve as a basis for this cytoprotection. We ...

That is, perhaps the β-PKC signaling pathway itself stimulates β-PKC transcription. In support of this idea, chronic α 1 -adrenergic stimulation in myocytes increases cPKC abundance 15 and induces ...

Breast cancer represents the most common cancer among women worldwide. Triple-negative breast cancer (TNBC), a particularly aggressive, metastatic, and drug-resistant subtype of breast cancer, poses a ...

Pertussis Toxin, PD098059, and GF 109203X, inhibitors of Gi, MEK, and protein kinase C, respectively, had no effect. The reported data suggest that the oxLDL-induced PI-3K activation is subsequent to ...