Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

The current foci of diabetic neuropathy research are oxidative stress, advanced glycation end products (AGEs), protein kinase C (PKC), and the polyol pathway.

We also examined the role of the protein kinase C (PKC) pathway in TNF-α effects in CVCs. Inhibition of the PKC pathway by pretreatment with a PKC-specific inhibitor, chelerythrine chloride (0.5 to ...

With a strong foundation laid over the past four years, the S&T Clusters model is emerging as an effective bridge between lab-scale innovation and field-scale implementation.