Background Fibrolamellar carcinoma (FLC), a rare and fatal liver cancer lacking effective drug therapy, is driven by the DNAJ ...

Cyclin D1–CDK4/6 phosphorylates GTSE1 in cancer cells, preventing its degradation and sustaining high levels across the cell cycle, which enhances proliferation and correlates with poor prognosis.

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Background: Our previously research has validated the effect of circELMOD3 on HCC tumor inhibition. However, further investigations are warranted to investigate the prognostic significance of ...

Early-onset CRC (EO-CRC) was associated with Flavonifractor plautii and increased bile acid, tryptophan, and choline ...

A team of University of Kentucky Markey Cancer Center researchers has found the mechanism that grants prostate cancer ...

Studying mice with cancer-linked cachexia, a condition typical of the disease that leads to muscle wasting and weight loss, they discovered a previously unrecognized pathway in the brain.

ROS activated the p53 signaling pathway and promoted the nuclear translocation ... Hdy-7 showed comparable cytotoxicity against five cancer cell lines, including Taxol resistant A549 Taxol cells.

Overproduced Wnt5a promotes the EMT of cancer cells via STAT3 signaling pathway. PCs-derived LIF inhibits tumor angiogenesis via Src/P53 signaling pathway. PCs are crucial components that regulate the ...

Mol Cancer Ther (2025) 24 (4): 497–510 ... The trend of MDM2 degradation observed with KT-253 treatments corresponds to the activation of the p53 pathway, as evidenced by an upregulation of proteomic ...