Disruption of core clock genes promotes tumor initiation and progression by regulating mechanisms such as the cell cycle, DNA repair, apoptosis ... of the p53-MDM2 pathway and DNA repair factors ...

Alopecia is an autoimmune disorder that causes non-scarring hair loss on the scalp and body that is experienced by almost 2% ...

Early-onset CRC (EO-CRC) was associated with Flavonifractor plautii and increased bile acid, tryptophan, and choline ...

The interplay between aging and cellular senescence reveals insights into chronic inflammation and potential strategies for enhancing healthspan and longevity.

The data to be presented encompasses five of the company's novel drug candidates: BCR-ABL tyrosine kinase inhibitor olverembatinib (HQP1351), Bcl-2 inhibitor lisaftoclax (APG-2575), FAK/ALK/ROS1 ...

[5] Pecina-Slaus (2010) Wnt signal transduction pathway and apoptosis ... [64] Spillare, Robles, Wang, Shen, Yu, Schellenberg, and Harris (1999) p53-mediated apoptosis is attenuated in Werner syndrome ...

RPL9 knockdown promote the apoptosis of B-ALL cells ... The findings indicate that RPL9 KD trigger nucleolar stress and activates the p53 signaling pathway in B-ALL cells. 3.6 Knocking down RPL9 ...

In contrast, neither weekly dosing of KT-253 at 0.3 mg/kg (which led to stasis) nor treatment with DS-3032 induced apoptosis (Fig. 4E). ALL and AML models also showed similar PD effect on p53 pathway ...

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