The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

Trump misstated $8 million spent on transgender mice, sparking debate on transgenic research and its importance in science.

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...

Robust Evidence of Disease Reversal in Severe Knock Out Mice Model Supports Tenaya's Clinical Development Plan to Evaluate TN-201 as a Potential Trea ...

Tenaya Therapeutics (TNYA) announced the publications of positive preclinical data for TN-201, the company’s gene therapy candidate for ...

each with a different gene knocked out. For these studies, they used the protozoan Plasmodium berghei, a close relative of Plasmodium falciparum that infects mice rather than humans. As hoped ...

Researchers at the University of Tsukuba have developed a vector that integrates the Cre enzyme gene with the specific DNA ...

Scientists have identified the Plvap gene as a key regulator of metabolism during fasting. Disabling it in mice prevented the ...

The team then edited the mouse genome using a streamlined strategy that combined three editing technologies: RNP-mediated knockout ... to modify seven genes. The gene editing resulted in mice ...

Scientists have created a new gene therapy for a debilitating ... The therapy worked as intended in knockout cells and was safe in wild-type mice, and also prevented death after birth in mice ...

A research team led by Prof. ZHANG Xin from High Magnetic Field laboratory, the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, has revealed how magnetic properties vary in ...