Mitochondria play a crucial role in acquiring pluripotency and determining cell fate. The mitochondrial unfolded protein ...

This useful study reports a method to detect and analyze a novel post-translational modification, lysine acetoacetylation (Kacac), finding it regulates protein metabolism pathways. The study unveils ...

Department of Pharmacy, Universidade Federal dos Vales do Jequitinhonha e Mucuri-UFVJM, Campus JK, Rodovia MGT 367 - Km 583, n° 5.000, Alto da Jacuba, CEP 39100-000 Diamantina, MG, Brazil ...

The pathogenesis of AD is multifactorial, involving hypotheses/mechanisms, such as amyloid-β (Aβ) plaques, tau protein hyperphosphorylation, cholinergic neuron damage, oxidative stress, and ...

Learn how environmental pollutants contribute to chronic illness and discover how the principles of environmental medicine ...

This study reveals a novel mechanism by which a centipede peptide toxin penetrates the cell membrane and directly binds to the intracellular IFMT motif of Nav channels, thereby completely abolishing ...

By modulating the acetylation status of histones (e.g., H3K9 ... transcription factor is the most well-known mechanism employed by hypoxic cells in this hostile microenvironment. Notably, there is a ...

This article reviews the complex molecular mechanisms of the poorly studied SIRT3 ... In general, SIRT3 inhibits the occurrence of FMT by regulating the acetylation levels of proteins such as GSK3β, ...