Cold brew and iced coffee can taste just fine, as does hot brewed stuff. So, why does hot coffee that's been allowed to cool usually taste so awful?

they observed trace amounts of a type of molecule called a lactone, indicating that an oxygenation reaction had occurred. Ultimately, they were able to determine the reaction conditions that ...

This type of reaction is a very important one because ... the team led by Thomas used two different enantiopure β-lactone derivatives with opposite configurations at their sole stereocentres ...