The “Varsity Blues” star has been married to his wife, Kimberly Van Der Beek (née Brook), since 2010. The couple share six children: daughters Olivia, Annabel, Emilia and Gwendolyn, and sons Joshua and Jeremiah. During his July 30 appearance on the “Today” show, Van Der Beek recalled the experience of discussing his diagnosis with his kids.

The "Dawson's Creek" star has shared a candid update about his ongoing cancer battle, eight months after revealing his diagnosis.

James Van Der Beek was diagnosed with colon cancer in 2023. He hopes more people will get screened earlier with the new Shield blood test.