Applegate's podcast cohost Jamie-Lynn Sigler informed the actress that vomiting and having diarrhea simultaneously is called "double dragoning."

Christina Applegate shared that she thinks her gastrointestinal symptoms are related to multiple sclerosis, explaining, "I get all the pain" from bowel movements.

Christina Applegate got vulnerable about the struggles she’s having as a result of multiple sclerosis. During a Tuesday broadcast of her podcast “MesSy,” which Applegate co-hosts with fellow actor Jamie-Lynn Sigler,