Sometimes, pain and depression create a vicious cycle in which pain worsens the symptoms of depression, then the resulting depression worsens the feelings of pain.

Chronic pain affects over 45 million Americans, with 65% of depression patients reporting at least one pain symptom. It ...

The Munich-based company's chief executive, Dr Clemens Fischer, said that pain patients around the world are "caught in a vicious cycle of pain, insomnia, limited mobility, and depression.