X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

When someone has Paget’s disease, it means the process of bone remodeling, which is the cycle of bone growth, has become abnormal. The result is that over time, bones can become larger, weaker ...

In humans, the most commonly affected bones are the pelvis, skull, femur, spine, tibia, humerus, scapula and mandible. In our rat, only the skull was involved, but several bones were affected ...

According to doctors, even though the exact cause of giant cell tumours is not known, in many cases, they have been linked to Paget's disease of bone. Paget's disease is a chronic condition that ...

Intensive bisphosphonate treatment does not confer a clinical advantage over treatment of symptoms alone in patients with Paget disease of bone. Findings from a UK study reveal that maintenance of ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...