Also known as osteitis deformans, it is a chronic bone disorder. When someone has Paget’s disease, it means the process of bone remodeling, which is the cycle of bone growth, has become abnormal.

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Paget disease of bone is a chronic skeletal disorder, common in European populations, that is characterized by abnormal bone remodeling. This disorder can involve one or several bones and is ...

The disease seems to occur in one of two patterns: monostotic (localized) and polyostotic (generalized). In humans, the most commonly affected bones are the pelvis, skull, femur, spine, tibia ...

Paget’s disease of the vulva is a rare type of skin disease that develops on the vulva. It is very slow to spread and is typically found in women who have been through menopause. In some cases, ...

Ipriflavone can block part of the process that leads to bone loss. Ipriflavone can block part of the process that leads to bone loss. A bone disease that can cause pain (Paget disease). Early ...

X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7).

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...