Bladder instillation of Escherichia coli lipopolysaccharide alters the muscle contractions in rat urinary bladder via a protein kinase C-related pathway. Toxicol Appl Pharmacol 2005;208:163–169.

Since their discovery in the late 1970s, protein kinase C (PKC) isozymes represent one of the most extensively studied signaling kinases. PKCs signal through multiple pathways and control the ...

Diabetes. 2005;54(6):1615-1625. The polyol pathway, shown schematically in Fig. 2, focuses on the enzyme aldose reductase. Aldose reductase normally has the function of reducing toxic aldehydes in ...

PKC, PKA, and PKG pathways control posttranslational regulation of receptor and channel proteins, and also have influences on gene expression.

Other molecules targeting the PKC pathway have been tried, but failed. For example, sotrastaurin, a pan-inhibitor of PKC isoforms showed drug activity but did not result in high response rates.

That’s because they’re likely acting far upstream of where a key problem is, namely in the PKC pathway. Since PKC inhibitors could act more directly, they might quench symptoms more quickly.

Another important pathway is the protein kinase C (PKC) pathway, which produces vascular endothelial growth factor (VEGF), leading to abnormal retina growth.

Signaling Pathway through Which Nicotine Promotes Breast Cancer Migration Discovered October 15, 2008 Nicotine interacts with its receptor to trigger a signaling cascade involving PKC and cdc42 ...

It also activates the classic PKC pathway, since the activator of PKC, diacylglycerol, is also formed from glyceraldehyde-3 phosphate. (Enlarge Image) ...