To investigate the role of p53, Oren says that they “wanted to perform [ChIP] to determine the extent of histone H2B ubiquitination at specific genomic sites, mainly those that are regulated by ...

Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of ...