The fragile structure of p53 gene reveals why this crucial cancer defense is so easily compromised, shedding light on the genetic Achilles' heel of many tumors. In a recent perspective published ...

For example, scientists have developed small molecules that can bind to mutant p53 and stabilize its faulty structure, ...

p53 has both transactivation and transrepression activity, and so controls the transcription of numerous genes. Among the p53 target genes are WAF1, an inhibitor of cyclin-dependent protein ...