Advances in gene-editing technologies like CRISPR are opening doors to directly correct p53 mutations in cancer cells. Additionally, researchers are exploring combination therapies that pair p53 ...

Much less commonly, p53 mutations can be inherited, and give rise to a syndrome known as Li-Fraumeni syndrome. EGFR mutations with lung cancer are usually somatic mutations acquired in the process ...

All the various tp53 and Trp53 clones used in cancer studies came from transformed cell lines; they all contained mutations. Once researchers redefined p53 as a tumor suppressor gene and generated ...

Other cancer-related mutations inactivate the genes that suppress ... many cancer cells carry two mutant copies of the gene that codes for p53, a multifunctional protein that normally senses ...

The aim of the present work was to establish an association between wood smoke exposure and lung cancer pathogenesis, and to analyze the effects of wood smoke on p53 and murine double minute 2 ...

“We need to define the role of risk-reduction surgery in reducing tubo-ovarian cancer risk for non-BRCA gene mutations to balance ... cell outgrowth, one p53 signature, one serous tubal intra ...