In evaluating the expression of various genes related to colorectal carcinogenesis, they also observed that, in 71% of the patients who had high levels of oxidative stress, the p53 gene presented ...

The researchers tested the extract against eight different types of colorectal cancer cells, representing various genetic profiles including some with and without the crucial p53 tumor suppressor ...

In this study, researchers restored p53 function in colorectal cancer cells, which led to slower cellular growth, increased cellular aging (senescence), and greater sensitivity to radiation therapy.

Colon cancer continues to be one of the leading causes ... Additionally, ferulic acid upregulated tumor suppressor proteins p53 and p21, which are pivotal in initiating apoptosis.

Evasion of apoptosis is a key hallmark of cancer – inactivation of p53 is a central mechanism by which tumours escape the body’s control mechanisms and promote tumour growth and proliferation.

Expert Rev Mol Diagn. 2008;8(3):277-288. Loss of heterozygosity (LOH) can be defined as the manifestation that results from the loss of large genomic regions. Lack of amplification of a particular ...