To create a knockout mouse, scientists genetically engineer the animal by disrupting a gene of interest. This may be done by deleting portions of the gene's DNA sequence to make it nonfunctional ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

In a groundbreaking advancement for families grappling with the challenges of Dravet syndrome, a rare and life-altering form ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a liver disease that progresses without symptoms and is associated ...

Colossal Biosciences leaders say the fluffy, golden-haired mice help validate their technique to “de-extinct” species, but ...

Scientists have identified the Plvap gene as a key regulator of metabolism during fasting. Disabling it in mice prevented the ...

By replacing the defective gene associated with Dravet syndrome in mice, scientists successfully alleviated symptoms without ...

Colossal Biosciences has announced the birth of the world’s first “woolly mouse”. The mouse has been genetically engineered ...

The team then edited the mouse genome using a streamlined strategy that combined three editing technologies: RNP-mediated knockout ... to modify seven genes. The gene editing resulted in mice ...

Metabolic dysfunction-associated steatohepatitis (MASH) is a polygenic disorder influenced by multiple genes, but their ...

To address this gap, researchers conducted a series of experiments that identified the NACHT and WD repeat domain-containing protein 1 (Nwd1) gene and its role in liver pathogenesis. This ...