A small amount of bile acids that are not taken up by hepatocytes enter the systemic circulation. Hepatocytes also efflux bile acids across the basolateral membrane via multidrug resistance ...

Thomas Horvath: Bile acids are cholesterol-derived compounds essential for digesting lipids and regulating metabolic pathways. They traverse a biochemical circuit known as enterohepatic circulation, ...

Bile-acid-mediated activation of FXR-α-signalling pathways regulate the enterohepatic recycling of bile acids, protect against their accumulation in the liver and inhibit their own biosynthesis.