Home games against the Dallas Cowboys, Pittsburg Steelers and Tampa Bay Buccaneers highlight the Lions' 2025 schedule. In addition to hosting NFC North rivals Green Bay Packers, Chicago Bears and Minnesota Vikings, the Lions will welcome in the Cowboys, Buccaneers (NFC South champions), Steelers, New York Giants and Cleveland Browns.

The Lions will play the lowest remaining seed after Wild Card Weekend, meaning that they will not be seeing the number two seed Philadelphia Eagles or the three-seeded Tampa Bay Buccaneers in the Divisional. There are four potential options for Detroit, and a deeper look into each is needed.

With the conclusion of the 2024 NFL regular season, the Detroit Lions have their 2025 opponents finalized. The schedule won't be revealed until the offseason, with the reveal traditionally coming in May, but the Lions now know their opponents.