"While there are clinical diagnoses of high (Cushing syndrome ... hormone (ACTH, the hormone that stimulates the production of cortisol), and periods of low cortisol occur. Levels may fluctuate ...

Stress and some conditions can increase cortisol levels. High cortisol can cause symptoms such as weight gain, acne, and fatigue. Doctors may refer to high cortisol as Cushing syndrome or ...

Agents that directly lower ACTH secretion by a pituitary adenoma represent an attractive option for the treatment of Cushing's disease, as these drugs directly target the pathogenesis of disease.

ACTH: Adrenocorticotrophic hormone ... Camden, NJ 08103, USA. Cushing's syndrome is a debilitating disorder which requires rapid reversal of hypercortisolemia to limit morbidity.