The Week 6 NFL schedule has arrived and one of the most-anticipated matchups is Dak Prescott and the Dallas Cowboys hosting Jared Goff the Detroit Lions. The Cowboys are coming off a last-second victory over the Pittsburgh Steelers,

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Cincinnati has had one of the most frustrating starts to the season of any team in the NFL, losing four games by a combined 15 points heading into the Week 6 NFL schedule. They racked up 520 total yards in a 41-38 loss to Baltimore last week,

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Even though they’ve beaten the Lions in six straight matchups, the Cowboys find themselves as three-point home underdogs. The 52-point total is the highest in Week 6 and one of only two games over 49. Here’s our prediction and pick for Sunday’s Lions vs. Cowboys matchup (4:25 p.m., FOX). You have to hand it to the Cowboys.

SportsLine's model simulated Cleveland Browns vs. Philadelphia Eagles 10,000 times and made its Week 6 NFL picks, predictions and best bets

With the question now being whether or not the Birds get back on track after a loss to the Buccaneers, here’s what the experts are predicting.

The well-rested Philadelphia Eagles will try to get back in the win column when they host the lowly Cleveland Browns in Week 6 at Lincoln Financial Field. The Eagles are 2-2 coming out of their bye week but have lost two of their past three games.