The overexpression of Bcl-2 by gene transfer abrogated both ROS generation and apoptosis induced by edelfosine in leukemic cells. Changes in the relative mitochondrial membrane potential were ...

To find answers, the team has worked with multiple melanoma cell lines, molecular markers and cancer therapies to decipher the decisive role of BCL-2 family proteins in senescent cell survival.

Venetoclax is a B cell lymphoma 2 (BCL-2) inhibitor that has shown promising ... The team identified a special six-gene pattern that can help predict which patients are more likely to respond ...