The two apoptosis pathways of interest are the extrinsic ... (DRs), and the intrinsic pathway is tightly controlled by the BCL-2 family of proteins and involves the disruption of mitochondrial ...

Figure 2: Inhibition of caspase 3, apoptosis (caspase ... distinct cellular stress pathways and signal that a stress has occurred through interactions with other BCL-2 family members.

Caenorhabditis elegans drp-1 and fis-2 Regulate Distinct Cell-Death Execution Pathways Downstream of ced-3 and Independent ... release of caspase activators from mitochondria during apoptosis. Here we ...

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, has improved AML treatment ... suggests potent activation of apoptosis by this two-drug combination; increased levels of γ ...