X denotes truncating mutation. PEST2 domain 345–377; UBA domain 387–436. *Two different mutations reported to cause this truncation. ‡ Results from splice site mutations (intron 7 ...

The disease seems to occur ... but several bones were affected, including the maxillary complex, nasal bones, right infraorbital fissure, right maxillary bone, lacrimal bone, malar process and ...

In Paget’s disease, the balance between bone removal and bone building gets ... Depending on the area affected, hearing loss and pinched spinal nerves are possible. The causes of Paget’s ...

In some cases, invasive cancer of the vulva is found below the area affected by Paget’s disease. The most common symptoms are itching and patches of red and white scaly skin on the vulva, similar in ...

PRISM (Paget's disease ... bone) instead of the parallel symmetry seen in normal lamellar bone. PDB is often asymptomatic, but patients can present with pain, deformity, or fracture in the ...

hip pain which may occur when Paget’s disease affects the pelvis or thigh bone. Depending on the bones affected, damage to joint cartilage can lead to arthritis. Changes in the bones of the ...

Before the discovery of agents that specifically inhibited osteoclastic bone resorption, there was no effective treatment for Paget's disease. This situation changed with the development for ...

Dear Doctors: I was recently diagnosed with Paget’s disease after suffering fatigue symptoms and muscle soreness in my neck, pelvic and lower-leg areas. I am sore and lethargic upon waking up in ...